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ALDH5A1 Antibody (NT)

Polyclonal Antibody to detect ALDH5A1 in human samples
Catalog #: 6752
$245.00

Product Details

Cat # +Size 6752-100
Size 100 μl
Antibody Target ALDH5A1
Alternate Name ALDH5A1; SSADH; Succinate-semialdehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase family 5 members A1; NAD (+)-dependent succinic semialdehyde dehydrogenase.
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This ALDH5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the N-terminal region of human ALDH5A1.
Accession # P51649
Gene ID 7915
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Species Reactivity Human.
Application Western blot, IHC, FACS.
Positive Control Western blot: 293 cell lysate, IHC: Human hepatocarcinoma, FACS: ATDC5 cells.
Application & Usage Western blot: ~1:1000, IHC: ~1:10-1:50, FACS: ~1:10–1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH5A1 (aldehyde dehydrogenase 5 family, member A1), also known as SSDH or SSADH, is a 535 amino acid protein that localizes to the mitochondria and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH5A1 is required for gamma-aminobutyric acid (GABA) recycling from the synaptic cleft. Mutations of ALDH5A1 lead to succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) that is characterized by severe ataxia and by mildly retarded psychomotor development.


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