Product Details
| Cat # +Size | 1708-1 |
|---|---|
| Size | 1 mg |
| Alternate Name | 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2 |
| Appearance | Light yellow solid |
| CAS # | 612847-09-3 |
| Molecular Formula | C₃₄H₂₉N₇O |
| Molecular Weight | 551.65 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO |
| SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7 |
| InChi | InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42) |
| InChi Key | BIWGYFZAEWGBAL-UHFFFAOYSA-N |
| PubChem CID | 10196499 |
| MDL Number | MFCD08705407 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC₅₀ = 58 nM (Akt1), 210 nM (Akt2) and 2.12 µM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 µM).
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