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Akt Inhibitor, Isozyme-Selective

An Akt inhibitor
Catalog #: 1708

In stock

$140.00

Product Details

Cat # +Size 1708-1
Size 1 mg
Alternate Name 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2
Appearance Light yellow solid
CAS # 612847-09-3
Molecular Formula C₃₄H₂₉N₇O
Molecular Weight 551.65
Purity ≥97% by HPLC
Solubility DMSO
SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7
InChi InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
InChi Key BIWGYFZAEWGBAL-UHFFFAOYSA-N
PubChem CID 10196499
MDL Number MFCD08705407
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC₅₀ = 58 nM (Akt1), 210 nM (Akt2) and 2.12 µM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 µM).


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