Akt Inhibitor (10-NCP)

A reversible and specific inhibitor of Akt activity in vitro
Catalog #: 2338 | abID:

Product Details

Alternate Name 10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride
Appearance White solid
CAS # 925681-41-0
Molecular Formula C₂₀H₂₅ClN₂O∙HCl
Molecular Weight 381.34
Purity ≥98% by HPLC
Solubility DMSO (60 mg/ml) or H2O (1 mg/ml)
InChi InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
PubChem CID 16760284
MDL Number MFCD09038570
Handling Protect from light and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1. Blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC₅₀ = 2–5 µM). Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.

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