Product Details
| Alternate Name | 10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride |
|---|---|
| Appearance | White solid |
| CAS # | 925681-41-0 |
| Molecular Formula | C₂₀H₂₅ClN₂O∙HCl |
| Molecular Weight | 381.34 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (60 mg/ml) or H2O (1 mg/ml) |
| SMILES | CCN(CC)CCCCN(C(C=C(Cl)C=C1)=C1O2)C3=C2C=CC=C3.[H]Cl |
| InChi | InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H |
| InChi Key | SVKSJUIYYCQZEC-UHFFFAOYSA-N |
| PubChem CID | 16760284 |
| MDL Number | MFCD09038570 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1. Blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC₅₀ = 2–5 µM). Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
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