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AKR1D1, human recombinant

Plays an important role in the metabolism of drugs, carcinogens and reactive aldehydes
Catalog #: 7358
$295.00

Product Details

Cat # +Size 7358-100
Size 100 μg
Alternate Name Aldo-keto reductase family 1, member D1, 3o5bred, CBAS2, SRD5B1
Gene Symbol AKR1D1
Gene ID 6718
Accession # P51857
Source E. coli
Appearance Liquid
Physical Form Description 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 100 mM NaCl and 20% glycerol.
Molecular Weight 39.5 kDa (346 aa, 1-326 aa + His Tag), confirmed by MALDI-TOF.
Purity by SDS-PAGE ≥90%
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MDLSAASHRI PLSDGNSIPI IGLGTYSEPK STPKGACATS VKVAIDTGYR HIDGAYIYQN EHEVGEAIRE KIAEGKVRRE DIFYCGKLWA TNHVPEMVRP TLERTLRVLQ LDYVDLYIIE VPMAFKPGDE IYPRDENGKW LYHKSNLCAT WEAMEACKDA GLVKSLGVSN FNRRQLELIL NKPGLKHKPV SNQVECHPYF TQPKLLKFCQ QH
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Aldo-keto reductase family 1, member D1, also known as AKR1D1, is a member of the AKR superfamily. The AKR family of proteins is soluble NADPH oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1D1 is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones which carry a delta (4)-3-one structure. AKR1D1 is highly expressed in liver, colon and testis. Deficiency of this enzyme may contribute to hepatic dysfunction. Recombinant human AKR1D1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


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