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AKR1C3 Inhibitor II

A highly potent and selective AKR1C3 inhibitor
Catalog #: 2404
SKU-Size Size Price Qty
2404-5 5 mg
$115.00
2404-25 25 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name 1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one
Appearance White to off-white solid
Molecular Formula C₁₆H₂₂N₂O₃S
Molecular Weight 322.42
Purity ≥98% by HPLC
Solubility DMSO
SMILES O=C1N(C2=CC=C(S(=O)(N3C(C)CCCC3)=O)C=C2)CCC1
InChi InChI=1S/C16H22N2O3S/c1-13-5-2-3-12-18(13)22(20,21)15-9-7-14(8-10-15)17-11-4-6-16(17)19/h7-10,13H,2-6,11-12H2,1H3
InChi Key KCSTYGPHSVKBQP-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM). Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.


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