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AKR1C3 Inhibitor I

A potent and selective AKR1C3 inhibitor
Catalog #: 2403

In stock

SKU-Size Size Price Qty
2403-5 5 mg
$95.00
2403-25 25 mg
$355.00
More Sizes Get Quote

Product Details

Alternate Name 3-(3,4-Dihydroisoquinolin2(1H)-ylsulfonyl)benzoic acid
Appearance White solid
Molecular Formula C₁₆H₁₅NO₄S
Molecular Weight 317.36
Purity ≥98% by HPLC
Solubility DMSO
SMILES O=S(C1=CC(C(O)=O)=CC=C1)(N2CCC(C=CC=C3)=C3C2)=O
InChi InChI=1S/C16H15NO4S/c18-16(19)13-6-3-7-15(10-13)22(20,21)17-9-8-12-4-1-2-5-14(12)11-17/h1-7,10H,8-9,11H2,(H,18,19)
InChi Key ZGVIUMKHTXKKOX-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. In repeat assays it showed an IC₅₀ of 0.013 ± 0.003 μM for AKR1C3, compared with 20.3 ± 3.8 μM against AKR1C1 and >30 μM against AKR1C2 and AKR1C4. This inhibitor also showed potency in a cellular assay, blocking the ability of AKR1C3 to metabolize a proven substrate. Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.


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