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AKR1B10, human recombinant

Involved in in the detoxification of aldehydes and ketones
Catalog #: 6339
SKU-Size Size Price Qty
6339-100 100 μg
$375.00
6339-1000 1 mg
$1,425.00
More Sizes Get Quote

Product Details

Alternate Name Aldo-keto reductase family 1, member B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HIS.
Gene Symbol AKR1B10
Gene ID 57016
Accession # O60218
Source E. coli
Appearance Liquid
Physical Form Description 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol.
Molecular Weight 36 kDa
Purity by SDS-PAGE ≥98%
Biological Activity The specific activity of AKR1B10 with 5 mM glyceraldehyde is approximately ~100 mU/mg. (Specific activity is calculated by the decrease of absorption at 340 nm in presence of 2-10 µg AKR1B10, 5mM glyceraldehyde, 200 µM NADPH in 0.1 M sodium phosphate buff
Amino Acid Sequence MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DP
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly expressed in small intestine, colon and adrenal gland. This protein is pathogenically involved in diabetic complications. It has been reported that AKR1B10 is overexpressed in human tumors, such as liver, breast, and lung cancer, and may play a critical role in the development and progression of cancer.


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