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AKR1A1 Antibody (CT)

Polyclonal Antibody to detect AKR1A1 in human samples
Catalog #: 6738
$245.00

Product Details

Cat # +Size 6738-100
Size 100 μl
Antibody Target AKR1A1
Alternate Name AKR1A1; ALDR1; ALR; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This AKR1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-325 amino acids from the C-terminal region of human AKR1A1.
Accession # P14550
Gene ID 10327
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Species Reactivity Human. Predicted cross reactivity with Mouse, Rat, Bovine and Pig samples.
Application Western blot, IHC
Positive Control Western blot: Y79, 293 cell line lysates, IHC: human hepatocarcinoma
Application & Usage Western blot: ~1:1000, IHC: ~1:10 – 1:50
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AKR1A1 (aldo-keto reductase family 1 member A1), also known as ALR (aldehyde reductase), DD3 (dihydrodiol dehydrogenase 3) or ALDR1 (alcohol dehydrogenase), is a widely and abundantly expressed member of the aldo-keto reductase (AKR) family of proteins. Members of the AKR family are soluble NADPH-dependent oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1A1 exists as a monomer and catalyzes the reduction of xenobiotic and biogenic aldehydes and ketones to their corresponding alcohols. In particular, AKR1A1 efficiently catalyzes medium-chain and aromatic aldehydes. AKR1A1 participates in the biosynthetic pathways of cholesterol and triglyceride and plays a role in the activation of polycyclic aromatic hydrocarbons (PAHs).


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