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Product Details
| Alternate Name | 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823 |
|---|---|
| Appearance | Tan powder |
| CAS # | 2627-69-2 |
| Molecular Formula | C₉H₁₄N₄O₅ |
| Molecular Weight | 258.23 |
| Purity | ≥98% by HPLC |
| Solubility | H₂O |
| SMILES | C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N |
| InChi | InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1 |
| InChi Key | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| PubChem CID | 17513 |
| MDL Number | MFCD00869751 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
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