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AHU-377

A potent and selective neprilysin inhibitor
Catalog #: 9520
SKU-Size Size Price Qty
9520-5 5 mg
$115.00
9520-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; Sacubitril
Appearance Light yellow oil
CAS # 149709-62-6
Molecular Formula C₂₄H₂₉NO₅
Molecular Weight 411.49
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
InChi InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
InChi Key PYNXFZCZUAOOQC-UTKZUKDTSA-N
PubChem CID 9811834
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AHU-377 is a prodrug that is activated in vivo by esterases to form an active compound LBQ657 which acts as a potent and selective neprilysin inhibitor. Neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. Inhibition of neprilysin prevents the degradation of natriuretic peptides and activates cGMP signaling pathways that regulate volume and blood pressure.


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