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AH10639 phosphate

An inhibitor of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase
Catalog #: B3342
SKU-Size Size Price Qty
B3342-5 5 mg
$85.00
B3342-25 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name Antibiotic O-12 NSC-98771 AH 10639
Appearance White to off-white solid
CAS # 84176-65-8
Molecular Formula C₁₂H₁₈N₆ · H₃PO₄
Molecular Weight 344.31
Purity ≥98%
Solubility >8 mg/ml Water
SMILES CC(C)C1=NC2=C(N=C(N=C2N=C1C(C)C)N)N.OP(=O)(O)O
InChi InChI=1S/C12H18N6.H3O4P/c1-5(2)7-8(6(3)4)16-11-9(15-7)10(13)17-12(14)18-11;1-5(2,3)4/h5-6H,1-4H3,(H4,13,14,16,17,18);(H3,1,2,3,4)
InChi Key YNQBQYASRYRNRY-UHFFFAOYSA-N
PubChem CID 264001
MDL Number MFCD00012733
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AH10639 phosphate is a novel inhibitor of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. AH10639 is significantly more potent and selective than pyrimethamine as an inhibitor of T. gondii dihydrofolate reductase (DHFR), with 50% inhibitory concentrations within the range of 0.018 to 0.033 µM.


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