Product Details
| Alternate Name | 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide; SIRT2 Inhibitor (Inactive Control) |
|---|---|
| Appearance | A crystalline solid |
| CAS # | 304896-21-7 |
| Molecular Formula | C₂₃H₁₃Cl₂N₃O₂ |
| Molecular Weight | 434.27 |
| Purity | ≥95% |
| Solubility | ~0.5 mg/ml in DMSO ~0.2 mg/ml in DMF |
| SMILES | C1=CC2=C(C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N)N=CC=C2 |
| InChi | InChI=1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)/b15-11+ |
| InChi Key | WRDKBSLEHFRKGG-RVDMUPIBSA-N |
| PubChem CID | 1372572 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
AGK7 is an inactive control and an isomer of AGK2. AGK2 is a cell-permeable, selective inhibitor of SIRT2 which is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase (IC₅₀ = 3.5 µM). AGK2 rescues α-synuclein toxicity in α-Syn-H4 cells while AGK7 does not affect α-synuclein aggregation. AGK7 inhibits SIRT3 with an IC₅₀ value greater than 5 µM and inhibits SIRT1 and SIRT2 with an IC₅₀ greater than 50 µM.
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