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AGK7

An inactive control and isomer of AGK2 (SIRT2 inhibitor)
Catalog #: B2843
SKU-Size Size Price Qty
B2843-1 1 mg
$65.00
B2843-5 5 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide; SIRT2 Inhibitor (Inactive Control)
Appearance A crystalline solid
CAS # 304896-21-7
Molecular Formula C₂₃H₁₃Cl₂N₃O₂
Molecular Weight 434.27
Purity ≥95%
Solubility ~0.5 mg/ml in DMSO
~0.2 mg/ml in DMF
SMILES C1=CC2=C(C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N)N=CC=C2
InChi InChI=1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)/b15-11+
InChi Key WRDKBSLEHFRKGG-RVDMUPIBSA-N
PubChem CID 1372572
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

AGK7 is an inactive control and an isomer of AGK2. AGK2 is a cell-permeable, selective inhibitor of SIRT2 which is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase (IC₅₀ = 3.5 µM). AGK2 rescues α-synuclein toxicity in α-Syn-H4 cells while AGK7 does not affect α-synuclein aggregation. AGK7 inhibits SIRT3 with an IC₅₀ value greater than 5 µM and inhibits SIRT1 and SIRT2 with an IC₅₀ greater than 50 µM.


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