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AG 1478

based on 2 citations in multiple journalsAG 147824.1 4
A potent EGFR Tyrosine Kinase (TK) inhibitor
Catalog #: 1800
SKU-Size Size Price Qty
1800-5 5 mg
1800-25 25 mg
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Product Details

Alternate Name 4-(3’-Chloroanilino)-6,7-dimethoxyquinazoline; Tyrphostin AG 1478
Appearance White solid
CAS # 175178-82-2
Molecular Formula C₁₆H₁₄ClN₃O₂
Molecular Weight 315.75
Purity ≥98% by HPLC
Solubility DMSO:Methanol 1:1 v/v (10 mg/ml), Ethanol (10 mg/ml)
InChi InChI=1S/C17H15ClN2O2/c1-21-16-8-13-14(7-11-4-3-5-12(18)6-11)19-10-20-15(13)9-17(16)22-2/h3-6,8-10H,7H2,1-2H3
PubChem CID 53429216
MDL Number MFCD00270914
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent EGFR Tyrosine Kinase (TK) inhibitor with an IC₅₀ of 3 nM. Only weakly inhibits PDGFR and HER2-NEU kinases (IC₅₀ >100 µM).

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Ito et al., Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-α/EGFR signaling. Am J Physiol Lung Cell Mol Physiol, Jun 2015; 308: L1178 - L1188.
Ito et al.,Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte growth factor/c-Met signaling. Am J Physiol Lung Cell Mol Physiol, Jul 2014; 307: L94 - L105.
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