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AG-014699 phosphate

A potent PARP1 inhibitor
Catalog #: 2890
SKU-Size Size Price Qty
2890-1 1 mg
$75.00
2890-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate; Rucaparib; PF-01367338
Appearance Light yellow to yellow solid
CAS # 459868-92-9
Molecular Formula C₁₉H₂₁FN₃O₅P
Molecular Weight 421.36
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
InChi InChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)
InChi Key FCCGJTKEKXUBFZ-UHFFFAOYSA-N
PubChem CID 9931953
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AG-014699 phosphate is a potent, cell-permeable inhibitor of PARP1 with Ki of 1.4 nM. It selectively binds to PARP 1 and inhibits the PARP1-mediated DNA repair, thus potentiating the genomic instability and apoptosis. Displays antineoplastic activity.


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