Product Details
| Alternate Name | N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, monohydrochloride |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1047645-82-8 |
| Molecular Formula | C₁₈H₁₇Cl₂FN₄OS • HCl |
| Molecular Weight | 463.8 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO >30 mg/ml) |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl |
| InChi | InChI=1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1 |
| InChi Key | YFQJOPFTGMHYNV-YDALLXLXSA-N |
| PubChem CID | 46843056 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Afuresertib is a potent and selective Akt inhibitor with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
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