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Product Details
| Alternate Name | N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4 |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 866893-90-5 |
| Molecular Formula | C₂₀H₂₈N₆O |
| Molecular Weight | 368.48 |
| Purity | ≥98% by NMR |
| Solubility | DMSO or EtOH |
| SMILES | CC[[email protected]](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1 |
| InChi | InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1 |
| InChi Key | YPYWONAECUVKHY-MRXNPFEDSA-N |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
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