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Aftin-4

An amyloid-β42 Inducer
Catalog #: 2574
SKU-Size Size Price Qty
2574-1 1 mg
$75.00
2574-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4
Appearance White to off-white solid
CAS # 866893-90-5
Molecular Formula C₂₀H₂₈N₆O
Molecular Weight 368.48
Purity ≥98% by NMR
Solubility DMSO or EtOH
SMILES CC[[email protected]](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1
InChi InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
InChi Key YPYWONAECUVKHY-MRXNPFEDSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.


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