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ADX-47273

A potent and selective mGluR5 receptor PAM (positive allosteric modulator)
Catalog #: 9562
SKU-Size Size Price Qty
9562-10 10 mg
$85.00
9562-50 50 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
Appearance Crystalline solid
CAS # 851881-60-2
Molecular Formula C₂₀H₁₇F₂N₃O₂
Molecular Weight 369.37
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES C1CC(CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F
InChi InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1
InChi Key VXQCCZHCFBHTTD-HNNXBMFYSA-N
PubChem CID 11383075
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC₅₀ = 0.17 μm, with no effect on other mGluR subtypes. ADX-47273 elevates extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex.


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