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AdipoRon

An adiponectin receptor agonist
Catalog #: 2565
SKU-Size Size Price Qty
2565-5 5 mg
$125.00
2565-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-(4-Benzylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Appearance White solid
CAS # 924416-43-3
Molecular Formula C₂₇H₂₈N₂O₃
Molecular Weight 428.54
Purity ≥98% by NMR
Solubility DMSO (~40 mg/ml) or EtOH (~ 20 mg/ml)
SMILES O=C(C1=CC=C(OCC(NC2CCN(CC3=CC=CC=C3)CC2)=O)C=C1)C4=CC=CC=C4
InChi InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
InChi Key SHHUPGSHGSNPDB-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective adiponectin receptor agonist (Kd = 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). Displays similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reverses insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorates diabetes in a genetically obese mouse model and prolongs the shortened lifespan of db/db mice on a high-fat diet.


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