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A synthetic retinoid acid analog
Catalog #: B2733
SKU-Size Size Price Qty
B2733-10 10 mg
B2733-50 50 mg
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Product Details

Alternate Name CD271, 6-(4-methoxy-3-tricyclo[,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Peptide Sequence N/A
Appearance White to light yellow solid
CAS # 106685-40-9
Molecular Formula C₂₈H₂₈O₃
Molecular Weight 412.53
Purity ≥98% by HPLC
Solubility ~5 mg/ml DMSO
InChi InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)/t17-,18+,19?,28?
PubChem CID 172088913
MDL Number MFCD03106112
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Adapalene is a synthetic Retinoic acid analog that acts as a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).

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