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ADAMTS6 (Human) ELISA Kit

A highly sensitive sandwich ELISA kit for the quantitative measurement of ADAMTS6

WARNING: This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E5111
$750.00

Product Details

Cat # +Size E5111-100
Size 96 assays
Detection Method Absorbance is measured at 450 nm
Species Reactivity Human
Applications The ELISA kit is used for the quantitative detection of ADAMTS6 in serum, plasma, tissue homogenates and other biological fluids
Features & Benefits ● Detection range: 31.25-2000 pg/ml
● Highly sensitive and specific
● Recovery Rate: 86104% for serum, 87-99% for EDTA plasma and 86-103% for heparin plasma
● Sensitivity: 18.75 pg/ml
● Assay Precision; Intra-Assay CV < 8% and Inter-Assay < 10%
Kit Components ● ELISA Microplate
● Wash Buffer (25X)
● Plate Sealers
● Lyophilized Standard (2000 pg)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody (Concentrated)
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ADAMTS6 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family which plays an important role in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Enhanced ADAMTS6 expression suppressed cell migration, invasion, and tumorigenesis, whereas knockdown promoted these characteristics. The extracellular signal-regulated kinase (ERK) pathway was partially involved in ADAMTS6-mediated inhibition of BC development, and miR-221-3p was identified as a predicted target for ADAMTS6. ADAMTS6 is a potential prognostic biomarker for Breast cancer. BioVision’s ADAMTS6 (Human) ELISA Kit is used for the quantitative detection of ADAMTS6 in serum, plasma, tissue homogenates and other biological fluids. It is based on the principle of sandwich ELISA. The capture antibody is pre-coated on 96-well plates. The standards, test samples and biotin conjugated detection antibody are added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin is added and unbound conjugates are washed away with wash buffer. The HRP enzymatic reaction is detected using TMB-substrate. Finally, an acidic stop solution terminates the enzymatic reaction. The color developed is directly proportional to the amount of ADAMTS6 in the sample.


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