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ADAMTS18 (Human) ELISA Kit

A highly sensitive sandwich ELISA kit for the quantitative measurement of ADAMTS18

WARNING: This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E5107
$750.00

Product Details

Cat # +Size E5107-100
Size 96 assays
Detection Method Absorbance is measured at 450 nm
Species Reactivity Human
Applications The ELISA kit is used for the quantitative detection of ADAMTS18 in serum, plasma, tissue homogenates and other biological fluids
Features & Benefits ● Recovery Rate: 88-101% for serum, 85-100% for EDTA plasma and 87-103% for heparin plasma
● Assay Precision; Intra-Assay CV < 8% and Inter-Assay < 10%
● Detection range: 78.125-5000 pg/ml
● Sensitivity: 46.875 pg/ml
● Highly sensitive and specific
Kit Components ● ELISA Microplate
● Wash Buffer (25X)
● Plate Sealers
● Lyophilized Standard (5000 pg)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody (Concentrated)
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are secreted metalloproteinases that are known for their crucial role in development, angiogenesis, inflammation and coagulation. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. It plays a major role in the assembly and degradation of the extracellular matrix (ECM). ADAMTS18 expression levels were significantly decreased in cervical cancer tissues compared with normal tissues and it decreased gradually from early stage to late stage. It plays an important role in cancer progression and metastasis in different cancer type and acts as a potential prognostic biomarker for cervical cancer. BioVision’s ADAMTS18 (Human) ELISA Kit is used for the quantitative detection of ADAMTS18 in serum, plasma, tissue homogenates and other biological fluids. It is based on the principle of sandwich ELISA. The capture antibody is pre-coated on 96-well plates. The standards, test samples and biotin conjugated detection antibody are added to the wells subsequently, and washed with wash buffer. HRP-Streptavidin is added and unbound conjugates are washed away with wash buffer. The HRP enzymatic reaction is detected using TMB-substrate. Finally, an acidic stop solution terminates the enzymatic reaction. The color developed is directly proportional to the amount of ADAMTS18 in the sample.


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