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Active Uteroglobin, Murine Recombinant

Exerts anti-inflammatory and anti-tumorigenic effects
Catalog #: P1761
SKU-Size Size Price Qty
P1761-10 10 µg
$245.00
P1761-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; PCB-binding protein; secretoglobin family 1A member 1; SCGB1A1; UTG; UGB; CC10
Gene ID 22287
Accession # Q06318
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight 16.7 kDa (disulfide-linked homodimer)
Purity by > 98% by SDS-PAGE and HPLC
Formulation Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4
Endotoxin Level < 0.1 ng/μg of protein (< 1 EU/μg)
Reconstitution Instructions Reconstitute in sterile deionized water to at least 100 µg/ml. The stock solution can be further diluted into other aqueous solutions.
Amino Acid Sequence DICPGFLQVL EALLMESESG YVASLKPFNP GSDLQNAGTQ LKRLVDTLPQ ETRINIMKLT EKILTSPLCK QDLRF
Specific Activity The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 µg/ml, corresponding to a specific activity of > 200 IU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Uteroglobin (SCGB1A1) is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Uteroglobin is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. Disruption of uteroglobin is associated with a susceptibility to asthma.


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