Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant

A biomarker in prostate cancer and a point of cell entry for SARS-CoV-2
Catalog #: P1679 | abID:

Product Details

Alternate Name Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin
Gene ID 7113
Accession # O15393
Source Sf9 (Baculovirus) cells
Appearance Sterile Filtered colorless solution
Physical Form Description Lyophilized
Molecular Weight 44.8 kDa (8xHis tag at the C-terminus)
Purity by SDS-PAGE > 85%
Formulation Lyophilized from a sterile filtered solution of PBS pH 7.4 containing 5% trehalose
Amino Acid Sequence Trp 106 – Gly 492 (with a substitution at R255Q)
Specific Activity The specific activity is > 2 mU/mg which was assayed using BioVision’s TMPRSS2 Inhibitor Screening Kit (Fluorometric) (Cat. No. K2113).
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. The protease domain of TMPRSS2 is also theorized to be cleaved and secreted extracellularly after autocleavage. Additionally, TMPRSS2 is shown to be upregulated by androgen in prostate cancer cells and downregulated in androgen-independent prostate cancer.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.