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Product Details
| Alternate Name | Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin |
|---|---|
| Gene ID | 7113 |
| Accession # | O15393 |
| Source | Sf9 (Baculovirus) cells |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | Liquid |
| Molecular Weight | 44.8 kDa (8xHis tag at the C-terminus) |
| Purity by SDS-PAGE | > 85% |
| Formulation | PBS pH 7.4 with 50% glycerol |
| Amino Acid Sequence | Trp 106 – Gly 492 (with a substitution at R255Q) |
| Specific Activity | The specific activity is > 2 mU/mg which was assayed using BioVision’s TMPRSS2 Inhibitor Screening Kit (Fluorometric) (Cat. No. K2113). |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. The protease domain of TMPRSS2 is also theorized to be cleaved and secreted extracellularly after autocleavage. Additionally, TMPRSS2 is shown to be upregulated by androgen in prostate cancer cells and downregulated in androgen-independent prostate cancer.
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