Product Details
| Alternate Name | Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin |
|---|---|
| Gene ID | 7113 |
| Accession # | O15393 |
| Source | Sf9 (Baculovirus) cells |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | Lyophilized |
| Molecular Weight | 44.8 kDa (8xHis tag at the C-terminus) |
| Purity by SDS-PAGE | > 85% |
| Formulation | Lyophilized from a sterile filtered solution of PBS pH 7.4 containing 5% trehalose |
| Amino Acid Sequence | Trp 106 – Gly 492 (with a substitution at R255Q) |
| Specific Activity | The specific activity is > 2 mU/mg which was assayed using BioVision’s TMPRSS2 Inhibitor Screening Kit (Fluorometric) (Cat. No. K2113). |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. The protease domain of TMPRSS2 is also theorized to be cleaved and secreted extracellularly after autocleavage. Additionally, TMPRSS2 is shown to be upregulated by androgen in prostate cancer cells and downregulated in androgen-independent prostate cancer.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
