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Product Details
| Alternate Name | Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin |
|---|---|
| Gene ID | 7113 |
| Accession # | O15393 |
| Source | Yeast |
| Physical Form Description | Liquid |
| Molecular Weight | 44.8 kDa (calculated) |
| Purity by SDS-PAGE | > 85% |
| Formulation | Tris-based buffer with 50% glycerol |
| Amino Acid Sequence | Partial sequence of TMPRSS2 (amino acids 106 to 492) with N-terminal 6xHis Tag |
| Specific Activity | Recombinant Human TMPRSS2 enzyme activity is measured by its ability to cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC), Km is 21.93 μM. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. TMPRSS2 is also shown to be upregulated by androgen in prostate cancer cells, and downregulated in androgen-independent prostate cancer.
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