Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant

A biomarker in prostate cancer and a point of cell entry for SARS-CoV-2
Catalog #: P1735 | abID:

Product Details

Alternate Name Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin
Gene ID 7113
Accession # O15393
Source Yeast
Physical Form Description Liquid
Molecular Weight 44.8 kDa (calculated)
Purity by SDS-PAGE > 85%
Formulation Tris-based buffer with 50% glycerol
Amino Acid Sequence Partial sequence of TMPRSS2 (amino acids 106 to 492) with N-terminal 6xHis Tag
Specific Activity Recombinant Human TMPRSS2 enzyme activity is measured by its ability to cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC), Km is 21.93 μM.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. TMPRSS2 is also shown to be upregulated by androgen in prostate cancer cells, and downregulated in androgen-independent prostate cancer.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.