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Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant

A biomarker in prostate cancer and a point of cell entry for SARS-CoV-2
Catalog #: P1735
SKU-Size Size Price Qty
P1735-10 10 µg
$195.00
P1735-50 50 µg
$445.00
More Sizes Get Quote

Product Details

Alternate Name Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin
Gene ID 7113
Accession # O15393
Source Yeast
Physical Form Description Liquid
Molecular Weight 44.8 kDa (calculated)
Purity by SDS-PAGE > 85%
Formulation Tris-based buffer with 50% glycerol
Amino Acid Sequence Partial sequence of TMPRSS2 (amino acids 106 to 492) with N-terminal 6xHis Tag
Specific Activity Recombinant Human TMPRSS2 enzyme activity is measured by its ability to cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC), Km is 21.93 μM.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. TMPRSS2 is also shown to be upregulated by androgen in prostate cancer cells, and downregulated in androgen-independent prostate cancer.


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