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Active Transglutaminase 2 (His-tagged), human recombinant

His tagged Human Transglutaminase 2 from E.Coli, AOF, ≥90% pure, biologically active.
Catalog #: 7700
SKU-Size Size Price Qty
7700-10 10 mU
$169.00
7700-100 100 mU
$499.00
More Sizes Get Quote

Product Details

Alternate Name TG2, tTG, tissue transglutaminase, transglutaminase C, TGC, protein-glutamine-gamma-glutamyltransferase, TGM2
Gene Symbol TGM2
Gene ID 7052
Accession # P21980
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized from 5 mg/ml solution in a proprietary buffer.
Molecular Weight 79.5 kDa (1-687 aa + N-terminal polyhistidine tag).
Purity by SDS-PAGE ≥90%
Biological Activity >400 mU/mg
Reconstitution Instructions Reconstitute to 0.1-0.5 mU/µl in 20 mM Tris, 120 mM NaCl, 10 mM DTT, pH 7.5 containing 20% glycerol. Aliquot and store at –80°C. Avoid repeated freezing and thawing cycles.
Amino Acid Sequence 1-687 aa of human transglutaminase 2 + N-terminal polyhistidine tag
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Tissue transglutaminase, a 78-kDa calcium dependent enzyme (EC 2.3.2.13), is found both in the intracellular and the extracellular spaces of various types of tissues. TG2 crosslinks proteins between the ε-amino group of a lysine residue and the γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation). TG2 also possesses deamidation, GTP-binding/hydrolyzing, and isopeptidase activities. Intracellular TG2 is thought to play an important role in apoptosis, while extracellular TG2 has been linked to cell adhesion, ECM stabilization, wound healing, receptor signaling, cellular proliferation, and cellular motility.


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