Active SIRT7, human recombinant

Intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
Catalog #: 7846 | abID: ab285974

Product Details

abID ab285974
Alternate Name NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
Gene Symbol SIRT7
Gene ID 51547
Accession # Q9NRC8
Source E. coli
Appearance Liquid
Physical Form Description 2 mg/ml in 50 mM Tris, pH 8.0, 100 mM NaCl, containing 5 mM DTT and 20% glycerol.
Molecular Weight 50.1 kDa (2-400 aa + N-terminal polyhistidine tag).
Purity by SDS-PAGE ≥85%
Biological Activity >1 µU/mg
Amino Acid Sequence 2-400 aa
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.

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