Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Active SIRT6 (His-tagged), human recombinant

His tagged Human SIRT6 from E.Coli, AOF, ≥90% pure, biologically active.
Catalog #: 7699
SKU-Size Size Price Qty
7699-20 20 µg
$155.00
7699-100 100 µg
$345.00
7699-1000 1 mg
$2,295.00
More Sizes Get Quote

Product Details

Alternate Name SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Gene Symbol SIRT6
Gene ID 51548
Accession # Q8N6T7
Source E. coli.
Appearance Liquid
Physical Form Description Human SIRT6 protein is a solution of 1 mg/ml in 50 mM Tris, 100 mM NaCl, pH 8.0 containing 20% glycerol.
Molecular Weight Human SIRT6 is a 41.3 kDa (1-355 aa + N-terminal polyhistidine tag) protein. It runs as ~30 kDa during SEC and ~47 kDa on a SDS-PAGE.
Purity by SDS-PAGE ≥90%
Biological Activity >3 mU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.