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Product Details
| Alternate Name | SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6 |
|---|---|
| Gene Symbol | SIRT6 |
| Gene ID | 51548 |
| Accession # | Q8N6T7 |
| Source | E. coli. |
| Appearance | Liquid |
| Physical Form Description | Human SIRT6 protein is a solution of 1 mg/ml in 50 mM Tris, 100 mM NaCl, pH 8.0 containing 20% glycerol. |
| Molecular Weight | Human SIRT6 is a 65.3 kDa (1-355 aa + N-terminal GST tag) protein. It runs as ~62 kDa on a SDS-PAGE. |
| Purity by SDS-PAGE | ≥85% |
| Biological Activity | >3 mU/mg |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.
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