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New

Active sFRP-4, Human Recombinant

A soluble modulator of Wnt signaling
Catalog #: P1709
$295.00

Product Details

Cat # +Size P1709-25
Size 25 µg
Alternate Name Secreted frizzled-related protein 4; DDC-4 SFRP4, FRP-4, FRPHE, PYL Frizzled protein, human endometrium; FRP-AP; frpHE; FRPHEMGC26498; FrzB2
Gene ID 6424
Accession # Q6FHJ7
Source CHO cells
Appearance Lyophilized protein
Physical Form Description Lyophilized protein powder
Molecular Weight 37.8 kDa
Purity by SDS-PAGE ≥ 95% by SDS-PAGE gel and HPLC analyses
Biological Activity Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25 ng/ml of Murine Wnt-3a.
Reconstitution Instructions Reconstitute to desired concentration using sterile water.
Amino Acid Sequence The target is expressed with the sequence (Val 19 to Val 346) of Human sFRP-4.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.


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