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Product Details
| Cat # +Size | P1709-25 |
|---|---|
| Size | 25 µg |
| Alternate Name | Secreted frizzled-related protein 4; DDC-4 SFRP4, FRP-4, FRPHE, PYL Frizzled protein, human endometrium; FRP-AP; frpHE; FRPHEMGC26498; FrzB2 |
| Gene ID | 6424 |
| Accession # | Q6FHJ7 |
| Source | CHO cells |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized protein powder |
| Molecular Weight | 37.8 kDa |
| Purity by SDS-PAGE | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Biological Activity | Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25 ng/ml of Murine Wnt-3a. |
| Reconstitution Instructions | Reconstitute to desired concentration using sterile water. |
| Amino Acid Sequence | The target is expressed with the sequence (Val 19 to Val 346) of Human sFRP-4. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.
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