Product Details
| Alternate Name | Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4 |
|---|---|
| Gene ID | 23569 |
| Accession # | Q9UM07 |
| Source | E.coli |
| Appearance | Liquid protein |
| Physical Form Description | Liquid |
| Molecular Weight | 75.8 kDa |
| Purity by SDS-PAGE | ≥ 85% |
| Amino Acid Sequence | Full length human PAD4 protein (amino acids 2 to 663) with N-terminal His tag |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.
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