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Active PAD4, Human Recombinant

Protein arginine deiminase associated with rheumatoid arthritis
Catalog #: P1720
SKU-Size Size Price Qty
P1720-50 50 µg
$325.00
P1720-100 100 µg
$545.00
More Sizes Get Quote

Product Details

Alternate Name Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4
Gene ID 23569
Accession # Q9UM07
Source E.coli
Appearance Liquid protein
Physical Form Description Liquid
Molecular Weight 75.8 kDa
Purity by SDS-PAGE ≥ 85%
Amino Acid Sequence Full length human PAD4 protein (amino acids 2 to 663) with N-terminal His tag
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.


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