Product Details
| abID | ab123227 |
|---|---|
| Cat # +Size | P1706-25 |
| Size | 25 µg |
| Alternate Name | arginine-rich, mutated in early stage tumors; Protein ARMET Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP) |
| Gene ID | 7873 |
| Accession # | P55145 |
| Source | E.coli |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized protein powder |
| Molecular Weight | 18.1 kDa |
| Purity by SDS-PAGE | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Biological Activity | Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml. |
| Reconstitution Instructions | Reconstitute to desired concentration using sterile water |
| Amino Acid Sequence | LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.
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