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New

Active MANF, Human Recombinant

A secreted neurotrophic factor that is mutated in a variety of tumors
Catalog #: P1706
$245.00

Product Details

Cat # +Size P1706-25
Size 25 µg
Alternate Name arginine-rich, mutated in early stage tumors; Protein ARMET Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)
Gene ID 7873
Accession # P55145
Source E.coli
Appearance Lyophilized powder
Physical Form Description Lyophilized protein powder
Molecular Weight 18.1 kDa
Purity by SDS-PAGE ≥ 98% by SDS-PAGE gel and HPLC analyses
Biological Activity Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
Reconstitution Instructions Reconstitute to desired concentration using sterile water
Amino Acid Sequence LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.


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