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Active Human Caspases Group I, Active Human

Set of recombinant proteases involved in apoptosis
Catalog #: K241
$295.00

Product Details

Cat # +Size K241-3-25
Size 3 x 25 units
Gene Symbol CASP1CASP4CASP5
Gene ID CASP1- 834CASP4- 837CASP5 -838
Accession # CASP1- NP_150634.1CASP4- P49662CASP5- P51878
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized powder
Reconstitution Instructions Reconstitute to 1 unit/µl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

The caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group I caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate YVAD-pNA (for caspase-1) and WEHD-pNA (for caspase-4 & -5).


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