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Active Human Calpain I

based on 7 citations in multiple journalsActive Human Calpain I74.1 4
A cysteine protease involved in apoptosis activation
Catalog #: 1134

Product Details

Cat # +Size 1134-100
Size 100 μg
Alternate Name CANP; muCL; CANP1; SPG76; CANPL1; muCANP; Calpain mu-type; calcium-activated neutral proteinase 1; calpain-1 catalytic subunit; calpain-1 large subunit; cell proliferation-inducing gene 30 protein; micromolar-calpain
Gene Symbol CAPN1
Gene ID 823
Accession # P07384
Source Human Erythrocyte
Appearance Liquid
Physical Form Description In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
Molecular Weight 110 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Ca²ᶧ-dependent cysteine proteinase with low Ca²ᶧrequirement (half maximal activation = 2 µM). Participates in the ATP release reaction of platelets stimulated with thrombin. Involves in apoptosis activation.

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Sirui Jiang, Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s disease. Aging Cell, Feb 2019;  30767411.
Wang et al., MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons. J. Biol. Chem., Jan 2015; 290: 168 - 182.
Chen et al., Effects of isoproterenol on aquaporin 5 levels in the parotid gland of mice in vivo. Am J Physiol Endocrinol Metab, Jan 2014; 306: E100 - E108.
Mitchell and Samulski. Mechanistic Insights into the Enhancement of Adeno-Associated Virus Transduction by Proteasome Inhibitors. J. Virol., Dec 2013; 87: 13035 - 13041.
Alison L. Müller et al., Activation of proteases and changes in Na+-K+-ATPase subunits in hearts subjected to ischemia-reperfusion. J Appl Physiol, Feb 2013; 114: 351 - 360.
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