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Active HIV-2 Protease Recombinant (GST-tagged)

≥85% Pure Active Recombinant HIV2 Protease (GST tagged) for inhibitor screening assays, activity studies, selectivity profiling, western blotting, ELISA, and numerous such applications.
Catalog #: 7851

In stock

SKU-Size Size Price Qty
7851-20 20 μg
$195.00
7851-100 100 μg
$645.00
More Sizes Get Quote

Product Details

Alternate Name HIV-2 retropepsin, HIV-2 Protease (PR2), cd05482
Gene Symbol HIV2 protease
Accession # Q68HL0
Source E. coli
Appearance Liquid
Physical Form Description 5 mg/ml in 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol
Molecular Weight 38.3 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31.5 kDa during SEC and SDS-PAGE analyses.
Purity by SDS-PAGE ≥85%
Biological Activity BioVision’s Active HIV-2 Protease has been tested for its activity using HIV-2 Protease Activity Assay Kit (Fluorometric) (K845-100).
Amino Acid Sequence 1-99 aa + N-terminal GST and C-terminal Poly-his tags
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is auto-catalytically released after formation of an immature viral particle. The enzyme subsequently cleaves the other parts of viral polyproteins resulting in the maturation of the virus. In HIV-infected patients, the enzyme is subjected to intensive mutagenesis and mutants resistant to applied medicines are produced as a result of the selection pressure. The mutation of HIV protease's active site or inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells. HIV-2 has been found to be less pathogenic than HIV-1. The mechanism of HIV-2 is not clearly defined, nor the difference from HIV-1, however the transmission rate is much lower in HIV-2 than HIV-1.


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