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Product Details
| Cat # +Size | P1708-25 |
|---|---|
| Size | 25 µg |
| Alternate Name | Antimicrobial peptide-57, AP-57, Colon-derived SUSD2 binding factor, CSBF, UNQ1833/PRO3446; Protein GPR15L; Secreted protein C10orf99 |
| Gene ID | 387695 |
| Accession # | Q6UWK7 |
| Source | E.coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized protein powder |
| Molecular Weight | 6.5 kDa |
| Purity by SDS-PAGE | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Biological Activity | Determined by its ability to chemoattract human PBMCs in a transwell-based migration assay. |
| Reconstitution Instructions | Reconstitute to desired concentration using sterile water. |
| Amino Acid Sequence | KRRPAKAWSG RRTRLCCHRV PSPNSTNLKG HHVRLCKPCK LEPEPRLWVV PGALPQV |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
GPR15L is a newly identified ligand for GPR15, a member of the G protein-coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15-expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth.
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