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Product Details
| Alternate Name | EPH Receptor B2; Developmentally-Regulated Eph-Related Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EPH-3; Tyrosine-Protein Kinase TYRO5 |
|---|---|
| Gene ID | 2048 |
| Accession # | P29323 |
| Source | Human cells |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | 78.5 kDa (predicted); 120 kDa (observed) |
| Purity by SDS-PAGE | > 90% |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Endotoxin Level | < 1.0 EU per μg as determined by the LAL method. |
| Biological Activity | Immobilized Active EphB2 (Fc Tag) 2 μg/ml (100 μl/well) can bind Ephrin B2 |
| Amino Acid Sequence | Val 19 to Ser 482 with C-terminal Fc Tag |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Ephrin Type-B Receptor 2 (EphB2) is a transmembrane receptor tyrosine kinase glycoprotein that functions through bidirectional signaling between adjacent cells. EphB2 functions in axon guidance during development, and also regulates development of dendrites and formation of synapses. EphB2 also controls angiogenesis, movement and adhesion of certain cells, and may function as a tumor suppressor. Some mutations of EphB2 have been associated with prostate and brain cancer.
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