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Active EIF2AK3, Human Recombinant

Key protein in cellular response to metabolic stresses
Catalog #: P1737
SKU-Size Size Price Qty
P1737-5 5 µg
P1737-10 10 µg
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Product Details

Alternate Name Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3; PERK; PEK; HsPEK; WRS
Gene ID 9451
Accession # Q9NZJ5
Source E.coli
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 125 kDa (calculated); 115 kDa (observed)
Purity by SDS-PAGE ≥ 70%
Formulation Liquid in 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
Amino Acid Sequence Amino acids 563 to 1115 with N-terminal GST tag
Specific Activity ≥ 15 nmol/min/mg as determined by the incorporation of Phosphorus-33-containing ATP into a SMAD3 protein substrate
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.


EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3), also known as PERK, is a metabolic-stress sensing protein kinase that phosphorylates and inactivates the alpha subunit of eukaryotic translation initiation factor 2 in response to various stress conditions. The action of EIF2AK3 directly results in a rapid reduction of translational initiation and protein synthesis. EIF2AK3 acts in response to various stress conditions such as low amino acid availability and misfolded proteins, and is thought to control mitochondrial morphology and function. Mutations in EIF2AK3 are associated with Wolcott-Rallison syndrome.

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