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Product Details
| Alternate Name | D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD |
|---|---|
| Gene Symbol | D2HGDH |
| Source | E. coli |
| Appearance | Dry powder |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | 39 kDa |
| Purity by SDS-PAGE | ≥99% |
| Reconstitution Instructions | Reconstitute in water to a concentration of 0.1-5 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use. |
| Amino Acid Sequence | Full-length his-tagged D2HGDH |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays.
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