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Active D-2-Hydroxyglutarate Dehydrogenase (D2HGDH), Recombinant

D2HGDH is an active protein that catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.
Catalog #: P1001
SKU-Size Size Price Qty
P1001-50 50 μg
$285.00
P1001-250 250 μg
$1,195.00
More Sizes Get Quote

Product Details

Alternate Name D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD
Gene Symbol D2HGDH
Source E. coli
Appearance Dry powder
Physical Form Description Lyophilized powder
Molecular Weight 39 kDa
Purity by SDS-PAGE ≥99%
Reconstitution Instructions Reconstitute in water to a concentration of 0.1-5 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use.
Amino Acid Sequence Full-length his-tagged D2HGDH
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays.


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