Product Details
| abID | ab285884 |
|---|---|
| Alternate Name | CTSS |
| Gene Symbol | CTSS |
| Gene ID | 1520 |
| Accession # | P25774 |
| Source | E. coli |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from proprietary buffer. |
| Molecular Weight | 23.9 kDa (115-331 aa) |
| Purity by SDS-PAGE | ≥90% |
| Biological Activity | BioVision’s Active Cathepsin S has been prepared by auto-catalytic activation of Procathepsin S (Cat # 7525) at low pH. The enzyme is fully active as seen from its ability to cleave a fluorogenic substrate Z-VVR-AFC (K144-100). |
| Reconstitution Instructions | Reconstitute in 50 mM sodium acetate, 100 mM NaCl (pH 5.5) to 0.1-1 mg/ml |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.
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Ainscough, Joseph S. et al. (2017) Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ, Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2748-E2757.
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