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Active Cathepsin D, Human Recombinant

An active Lysosomal aspartyl protease
Catalog #: 9229
SKU-Size Size Price Qty
9229-10 10 µg
$180.00
9229-50 50 µg
$630.00
9229-100 100 µg
$995.00
More Sizes Get Quote

Product Details

Alternate Name Procathepsin D, CTSD
Gene Symbol CTSD
Gene ID 1509
Accession # P07339
Source E. coli
Appearance Freeze-Dried
Physical Form Description Freeze-dried from proprietary buffer
Molecular Weight 45.1 kDa
Purity by SDS-PAGE ≥80%
Purity by ≥80%
Biological Activity specific activity >100 pmol/min/mg and IC50 = 0.32 pM
Reconstitution Instructions Reconstitute to 1 mg/ml in water
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D. BioVision’s Active Human Cathepsin D is a proteolytically active, non-glycosylated enzyme expressed, purified and activated by proprietary methods.


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