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Active Caspase-1, rat recombinant

A cysteine protease involved in apoptosis 
Catalog #: 7524
SKU-Size Size Price Qty
7524-25 25 units
7524-100 100 units
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Product Details

Alternate Name Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.
Gene Symbol Casp1
Accession # P43527
Source E. coli
Appearance Semi-Dry
Physical Form Description Semi-Dry
Molecular Weight ~ 34.6 KDa
Biological Activity The caspase-1 is routinely tested at BioVision for its ability to cleave these two substrates Ac-YVAD-pNA (Cat. #1104-200) or Ac-YVAD-AFC (1103-200).
Reconstitution Instructions Reconstitute to 1 unit per μl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284 amino acids with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques.

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Crowell, Kristen T. et al. (2017) Inability to replete white adipose tissue during recovery phase of sepsis is associated with increased autophagy, apoptosis, and proteasome activity, Am J Physiol Regul Integr Comp Physiol. 2017 Mar 1;312(3):R388-R399.
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