Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Active Caspase-1, rat recombinant

A cysteine protease involved in apoptosis 
Catalog #: 7524
SKU-Size Size Price Qty
7524-25 25 units
$265.00
7524-100 100 units
$465.00
More Sizes Get Quote

Product Details

Alternate Name Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45.
Gene Symbol Casp1
Accession # P43527
Source E. coli
Appearance Semi-Dry
Physical Form Description Semi-Dry
Molecular Weight ~ 34.6 KDa
Biological Activity The caspase-1 is routinely tested at BioVision for its ability to cleave these two substrates Ac-YVAD-pNA (Cat. #1104-200) or Ac-YVAD-AFC (1103-200).
Reconstitution Instructions Reconstitute to 1 unit per μl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284 amino acids with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Crowell, Kristen T. et al. (2017) Inability to replete white adipose tissue during recovery phase of sepsis is associated with increased autophagy, apoptosis, and proteasome activity, Am J Physiol Regul Integr Comp Physiol. 2017 Mar 1;312(3):R388-R399.
For more citations of this product click here