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Activated Protein C, Human Plasma

Regulates blood coagulation by inactivating factors Va and VIIIa
Catalog #: 7683
$225.00

Product Details

Cat # +Size 7683-50
Size 50 μg
Alternate Name Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.
Gene Symbol PROC
Gene ID 5624
Accession # P04070
Source Human Plasma
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4
Molecular Weight 56 kDa
Purity by SDS-PAGE ≥95%
Biological Activity Lot dependent
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on SDS-PAGE. Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.


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