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Activated Protein C (APC) Inhibitor Screening Kit (Colorimetric)

High-throughput compatible, quick and easy screening for Activated Protein C ligands; Includes human recombinant APC
Catalog #: K427

In stock


Product Details

Cat # +Size K427-100
Size 100 assays
Kit Summary • Detection method - Colorimetric (OD 405 nm)
• Species reactivity - N/A
• Applications - Screening of drugs and novel ligands for interaction with human recombinant Activated Protein C
Detection Method Detection method - Colorimetric (OD 405 nm)
Applications Screening of drugs and novel ligands for interaction with human recombinant Activated Protein C
Features & Benefits • Simple, highly sensitive, high-throughput compatible
• Rapid screening of Activated Protein C ligands
• Kit includes PPACK (APC inhibitor) and a stable, recombinant human APC
Kit Components • APC Assay Buffer
• APC Enzyme
• APC Substrate
• APC Inhibitor (1 mM PPACK Dihydrochloride)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Activated protein C (APC) (, a Vitamin K dependent serine protease, is formed by activation of Protein C by Thrombomodulin bound on the surface of endothelial cells. By degrading coagulation factors Va and VIIIa, APC inhibits blood coagulation which helps in the prevention of thrombosis. Blood coagulation can be stimulated by inhibition of APC. Thus, APC inhibitors play an important role in the treatment of disease like Haemophilia. BioVision’s APC Inhibitor Screening Kit can be used to screen for potent inhibitors of APC activity. It utilizes the proteolytic activity of an active APC on a peptide substrate which releases a colored product. The released product can be easily quantified using an absorbance microplate reader. In the presence of an APC inhibitor, the enzyme decreases/loses activity resulting in lower/no absorbance. This assay kit is simple and can be used to identify and characterize APC inhibitors in a high-throughput format. As a control, we provide the inhibitor PPACK dihydrochloride - a known APC inhibitor.

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