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Actinomycin D

based on 1 citations in multiple journalsActinomycin D14.1 4
An antineoplastic antibiotic
Catalog #: 1036
SKU-Size Size Price Qty
1036-50 50 µl
1036-5MG 5 mg
1036-50MG 50 mg
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Product Details

Alternate Name Actinomycin C1, Actinomycin IV, Dactinomycin
Appearance • Liquid
• Solid
Formulation • 1036-50 (10 mM in DMSO)
• 1036-5MG (Solid)
• 1036-50MG (Solid)
CAS # 50-76-0
Molecular Formula C₆₂H₈₆N₁₂O₁₆
Molecular Weight 1255.5
Purity >98% by TLC
Solubility DMSO (20 mg/ml)
SMILES CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChi InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)
PubChem CID 2019
MDL Number MFCD00005033
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


An antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines (1).

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Goplen D et al. {alpha}B-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells. Am J Pathol. 2010; Oct 2010; 177: 1618 - 1628.
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