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Actin Polymerization/ Depolymerization Assay Kit (Fluorometric)

The most sensitive assay kit in the market for the detection of actin polymerization/depolymerization
Catalog #: K457

In stock

$595.00

Product Details

Cat # +Size K457-100
Size 100 assays
Kit Summary • Fluorescence (Ex/Em: 365/410 nm)
• Study and quantitate the effect of different compounds, proteins and tissue extracts on Actin polymerization and/or depolymerization
• Evaluation of critical concentrations of actin polymerization in different conditions
Detection Method Fluorescence (Ex/Em: 365/410 nm)
Species Reactivity Not Applicable
Applications • Study and quantitate the effect of different compounds, proteins and tissue extracts on Actin polymerization and/or depolymerization
• Evaluation of critical concentrations of actin polymerization in different conditions
Kit Components • Buffer G
• Buffer P (10X)
• Labeled Rabbit Muscle Actin
• ATP (100 mM)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Actin, a highly conserved and abundant protein in eukaryotic cells, is one of the major components of cytoskeleton. It can be found as monomeric globular protein, called G actin or it can polymerize into filamentous actin, named F actin. Actin plays major roles in cell division, cell motility, cell signaling, organelle movement, etc. Mammals have 6 isoforms of Actin, which can be divided into 3 classes, α, β and γ. Muscle Actin is α class and all other non-muscle actins belong to β and γ -classes. Understanding the effect of different drugs, proteins, etc. on Actin Polymerization and Depolymerization is very important for understanding cellular machinery, more importantly because Cytoskeleton is a very important target for cancer therapy. BioVision’s Actin Polymerization/Depolymerization Assay Kit can be used to study the effect of different compounds, proteins and tissue extracts on Actin polymerization and depolymerization. The kit utilizes a proprietary Pyrene-labeled Actin molecule that develops a higher fluorescent signal if it undergoes polymerization. The signal can be easily detected using a fluorescence microplate reader. The assay is simple, high- throughput compatible, and can be completed in less than three hours


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