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Aclacinomycin A hydrochloride

A specific inhibitor of the 20S proteasome chymotrypsin-like activity.
Catalog #: B1905
SKU-Size Size Price Qty
B1905-1 1 mg
B1905-5 5 mg
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Product Details

Alternate Name Aclarubicin hydrochloride
Appearance Orange solid
CAS # 75443-99-1
Molecular Formula C₄₂H₅₃NO₁₅ • HCl
Molecular Weight 848.3
Purity ≥90% by HPLC
Solubility DMSO (~ 30 mg/ml)
InChi InChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45) 56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3; 1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1
PubChem CID 153751
MDL Number MFCD00133024
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.

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