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ACK1, Human Recombinant

Non-receptor tyrosine-protein kinase that is implicated in cell migration, survival, growth and proliferation
Catalog #: P1499
SKU-Size Size Price Qty
P1499-10 10 μg
P1499-50 50 μg
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Product Details

Alternate Name Tyrosine kinase non-receptor protein 2, CDC42 kinase 1, TNK2
Gene Symbol TNK2
Gene ID 10188
Accession # Q07912
Source Insect Cells (sf9)
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 43.5 KDa (aa 110-476, N-His tag)
Purity by >95%
Biological Activity The specific activity is ≥ 500 U/mg. Specific activity was tested using Biovision ADPsensor™ Universal Kinase Activity Assay Kit (Cat# K212).
Amino Acid Sequence aa 110-476
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.


Activated CDC42 kinase 1, also known as ACK1, is an enzyme that is encoded by the TNK2 gene in humans. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain.

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