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ACHE Antibody (NT)

Polyclonal Antibody to detect ACHE in human samples
Catalog #: 6706
$245.00

Product Details

Cat # +Size 6706-100
Size 100 μl
Antibody Target ACHE
Alternate Name ACHE; Acetylcholinesterase
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This ACHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the N-terminal region of human ACHE.
Accession # P22303
Gene ID ACHE
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Species Reactivity Human
Application Western blot, IHC, IF, FACS
Positive Control Western blot: Jurkat, Raji and Y79 cell lysate, IHC: human brain tissue, IF: NCI-H460 cells, FACS: NCI-H460 cells
Application & Usage Western blot: ~1:1000, FACS: ~1:10–1:50, IHC: ~1:10-1:50, IF: 1:10-1:50.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acetylcholinesterase (AChE) hydrolyzes acetylcholine at synaptic junctions. Alternative mRNA splicing gives rise to three forms of AChE. It plays a role in neuronal apoptosis. The T form, also known as the asymmetric form, is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer’s disease. However, AChE activity is increased around amyloid plaques, which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.


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