Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

ACHE Antibody (CT) (Clone 684CT8.3.4)

Monoclonal Antibody to detect ACHE in human, mouse and rat samples
Catalog #: 6707
$245.00

Product Details

Cat # +Size 6707-100
Size 100 μl
Antibody Target ACHE
Alternate Name ACHE; Acetylcholinesterase
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen This ACHE antibody is generated from mouse immunized with a KLH conjugated synthetic peptide between 587-611 amino acids from the C-terminal region of human ACHE.
Accession # P22303
Gene ID ACHE
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Species Reactivity Human, mouse, rat
Application Western blot
Positive Control Western blot: Raji, Jurkat, COS7, NIH3T3 mouse and rat cerebellum lysates
Application & Usage Western blot: ~1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acetylcholinesterase (AChE) hydrolyzes acetylcholine at synaptic junctions. Alternative mRNA splicing gives rise to three forms of AChE. It plays a role in neuronal apoptosis. The T form, also known as the asymmetric form, is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer’s disease. However, AChE activity is increased around amyloid plaques, which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.